Why is fast speed of kill important? Well, it takes around 48 hours for fleas to begin laying eggs once they have started to feed. If we can kill the fleas before they can lay any eggs, then this will break the life cycle and fix your flea problem faster.

In a study done by Dryden, Smith, Payne and McTier in 2005, selamectin (Revolution), fipronil-(S)-methoprene (Frontline) and imidacloprid(Advantage & Advocate)were compared to see which flea treatment product kills fleas the fastest. They were tested for speed of kill at days 2, 7, 14, 21 and 28, to simulate what would happen over the course of a monthly flea treatment.

Following initial application, imidacloprid was the only product to cause significant flea reduction in 6 hours.  By 24 hours of applications, all three products had killed at least 96.7% of fleas on the pet. So basically, after a day, almost all of the fleas on the pet will be killed regardless of which product you use.

One week after treatment, all three products were still going strong. Each product reduced flea populations by around 70% in 6 hours, and had killed 99.4% of fleas in 24 hours. This is good – no fleas are living long enough to lay eggs and reinfest the environment.

Three weeks after initial application, the speed of kill for all the products had decreased significantly, with none of the formulations killing fleas within 6 hours.  At 28 days after treatment – selamectin killed 99% in 48 hours, fipronil-(s)-methoprene killed 86.4% within 48 hours, and imidacloprid killed 72.6% within 48 hours. This is where things start to drop off, which is why these products need to be used monthly.

From these results, we can see is that there is no real difference between any of the products for the majority of the time. Imidacloprid gets a jump start on the other product and starts killing fleas sooner, but by 24 hours they are mostly the same. At the end of the month, selamectin has the most staying power, still killing 99% of fleas before they are able to breed.

Interestingly, another study (McCoy et al, 2008)- showed that Revolution is more effective than Frontline Plus and Advantage in reducing the amount of blood consumed by fleas.

In reality, it doesn’t matter which of these products you use. They are all excellent products and will do a much better job of killing fleas than any flea shampoos, flea collars, flea powders or natural flea treaments.

To a flea free pet!

Dr. Simon

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